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Why is the third position on tRNA's anticodon flexible (my book calls it wobble) but not the first or second?
Answer 1:

"Wobble" is indeed the correct term. The experimental observation is that the third position, in terms of the actual chemistry or steric criteria, is not as "stringent" as that for the first 2 positions. Because of the flexibility in the 3rd position, the genetic code is degenerate. Why is it this way? Various ideas about the value of a degenerate code have been posited, most having to do with ideas of mutation mechanisms.



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