|At which phase of cell cycle does the
mitochondrial DNA synthesis takes place?|
|Question Date: 2012-12-31|
According to Clayton (1982) and other studies
in the late 80s and early 90s, mitochondrial DNA
replication is not restricted to any one phase
of the cell cycle (in mice). In some of the
studies, it seems they even found mtDNA
replication happening more than once in the cell
Mitochondria are bacteria that have given
control of their division over to the host cell,
meaning that they divide when the cell tells
them to, but they still divide like other
bacteria, by binary fission. I don't know when
the signal to the mitochondria to divide goes
out; I'll bet it's in interphase, but it might
happen at other times than when the cell is
getting ready to divide.
Replication of mitochondrial DNA is not
dependent on the cell cycle, but rather the
temperature of the cell. Mitochondria do need to
replicate their DNA before cell division,
however they can do several rounds of
replication where as the cell can only do one.
For the most part though, they do their
replication in the G1 phase or interphase.
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