These are very interesting questions; not a lot
of people know about the spleen and try to learn
so much about it.
The spleen is located to the left of the
stomach in the upper abdomen. It's an organ mostly
found in vertebrates, like humans. Two of its most
important functions are to filter and store blood.
Healthy red blood cells pass through the spleen,
but unhealthy red blood cells are broken down by
macrophages, large white blood cells, in the
spleen. Any useful components of old cells,
especially iron, are stored in the spleen. The
iron is then transferred to the bone marrow to
help with hemoglobin production; hemoglobin is a
protein in the blood that helps transport oxygen
from the lungs to the rest of your body. The
spleen also stores extra blood, so if the body is
ever in need of extra blood the spleen suppled it.
The spleen is like a large lymph node so if it
ever has to be surgically removed, other lymph
nodes and the liver replace its job functions. In
other words, you can live without your spleen. In
terms of your immune system, though, loss of
spleen function does make a person more vulnerable
to infections because it does so much for your
body. If someone does get his or her spleen
removed, doctors prescribe some injections and
antibiotics to protect the patient.
When there is an increase in abnormal
erythrocytes, the spleen has to work harder than
usual which causes it to enlarge. Enlarged spleen,
or splenomegaly, can cause hypersplenism (Banti
syndrome) where the spleen starts to prematurely
destroy blood cells. Also, as the spleen enlarges
it starts to filter both abnormal and healthy
blood cells causing less healthy blood cells in
the bloodstream. Since there are more blood cells
being filtered than normal function, the spleen
can get clogged. There are many reasons the spleen
can become enlarged. Sometimes treatments are
offered, and the first suggestion is to not get it
Pathology is the study and diagnosis of disease,
so no, it does not cause spleen "pathology". I'm
afraid I don't understand this particular
question. But an increase in abnormal red blood
cells does caused an enlarged spleen, as mentioned
Good luck with the rest of your research!
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