Yes, it is possible. All you need is to
deposit a chiral substance on the surface
of the particles that build up your thin layer.
Any time a racemic mixture (the mixture of
two enantiomers) interacts with a surface that is
chiral, one of the enantiomers is going to be
attracted more strongly to that surface than the
other, and that is the basis for
If you would like a deep insight into the what
has been done by this technique, you can ask your
librarian for a copy of the paper: Abdoul-Enein,
H. Y.; El-Awady, M. I.; Heard, C. M., Nicholls, P.
J.Applications of thin-layer chromatography in
enantiomeric chiral analysis - an overview
Biomedical Chromatography, vol. 13, 531-537, 1999I.
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