The universe has a lot of impact on humans. For example, probably all the heavy elements on Earth (and in our body) come from some supernovae (exploding massive stars at the end of their lives), somewhere in the universe long time ago. The reason is that, all the heavy elements are produced by nuclear reactions inside stars. After a supernova explodes, these heavy elements are released into space, and have the chance to form new stars/planets, and become part of we humans.

Humans are part of the universe, and made of the universe's matter. It's the reason why humans can exist, and everything they do.

This is an interesting philosophical question. I think the universe impacts humans primarily in the sense that humans exist within the universe. The evolution of life, the development of galaxies, stars, planets, and other astronomical objects all occurs within this context.