In my research, we sometimes use a tiny probe in an atomic force microscope to pull on molecules
from muscle or bone. We often find that we can
attach the molecules to the microscope slide and
the microscope's probe tight enough to pull with
high force simply by mashing the probe tip against
the molecules on the slide.
It seems to be a new procedure, where the laser 'melts' the proteins in muscle and they cool and solidify; and other proteins are often added to make a stronger weld. This was from a 1998 online article.
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